منابع مشابه
Alignment of whole genomes.
A new system for aligning whole genome sequences is described. Using an efficient data structure called a suffix tree, the system is able to rapidly align sequences containing millions of nucleotides. Its use is demonstrated on two strains of Mycoplasma tuberculosis, on two less similar species of Mycoplasma bacteria and on two syntenic sequences from human chromosome 12 and mouse chromosome 6....
متن کاملMugsy: fast multiple alignment of closely related whole genomes
MOTIVATION The relative ease and low cost of current generation sequencing technologies has led to a dramatic increase in the number of sequenced genomes for species across the tree of life. This increasing volume of data requires tools that can quickly compare multiple whole-genome sequences, millions of base pairs in length, to aid in the study of populations, pan-genomes, and genome evolutio...
متن کاملParametric Alignment of Drosophila Genomes
The classic algorithms of Needleman-Wunsch and Smith-Waterman find a maximum a posteriori probability alignment for a pair hidden Markov model (PHMM). To process large genomes that have undergone complex genome rearrangements, almost all existing whole genome alignment methods apply fast heuristics to divide genomes into small pieces that are suitable for Needleman-Wunsch alignment. In these al...
متن کاملUsing Whole Chloroplast Genomes
320 American Journal of Botany 99(2): 320–329, 2012; http://www.amjbot.org/ © 2012 Botanical Society of America Reliable identifi cation of variation below the species level would provide valuable insight into subspecies ranges, habitat differentiation, and patterns of gene fl ow and migration. Additionally, it would aid in conservation of important variation within species. For example, the co...
متن کاملSequencing Whole Genomes
There are two general strategies for sequencing a complete genome. The method preferred by the Human Genome Project is the hierarchical shotgun sequencing method. In this approach, genomic DNA is cut into pieces of about 150 Mb and inserted into BAC vectors, transformed into E. coli where they are replicated and stored. The BAC inserts are isolated and mapped to determine the order of each clon...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1999
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/27.11.2369